Let's say you've got a bunch of data: addresses, or lists of your DVDs, or whatever. It's not world-changing high-transaction information, but you want it in a good storage format. Do you create a spreadsheet and put your info in that, or do you go straight for the higher-end solution and create a Base database?
The good news, it doesn't matter that much. Generally, I would recommend that you start with the spreadsheet, then if necessary go to the Base format. The transition isn't a matter of right-clicking and choosing Convert but it's not bad. Pasting, essentially.