FatRat comes with many very interesting options. For one, it can download from HTTP(S)/FTP, RapidShare free and even YouTube. But FatRat can also download torrents, (it has BitTorrent support) has RSS feed support + special functions for TV shows and podcasts, support for SOCKS5 and HTTP proxies and even remote control via Jabber and a web interface and of course, a scheduler.
Plowshare is a command-line downloader and uploader for some of the most popular file-sharing websites. It works on UNIX-like systems and presently supports: Megaupload, Rapidshare, 2Shared, 4Shared, ZShare, Badongo, DepositFiles and Mediafire.
JDownloader simplifies downloading files from One-Click-Hosters like Rapidshare.com or Megaupload.com - not only for users with a premium account but also for users who don't pay. The most important, noticeable change is that JDownloader 0.7 (7.569) is a lot faster than the previous versions. Another interesting change is that now it supports anti-captcha for more than 60 websites.
Slimrat is an easy to use rapidshare downloader which can be used from command line or GUI. It can download files from these services: